Detection of simultaneous multi-mutations using base-quenched probe
نویسندگان
چکیده
منابع مشابه
Simultaneous detection of the C282Y, H63D and S65C mutations in the hemochromatosis gene using quenched-FRET real-time PCR.
Hereditary hemochromatosis (HH) is a common autosomal disorder of iron metabolism mainly affecting Caucasian populations. Three recurrent disease-associated mutations have been detected in the hemochromatosis gene (HFE): C282Y, H63D, and S65C. Although HH phenotype has been associated with all three mutations, C282Y is considered the most relevant mutation responsible for hemochromatosis. Clini...
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ژورنال
عنوان ژورنال: Analytical Biochemistry
سال: 2018
ISSN: 0003-2697
DOI: 10.1016/j.ab.2017.12.011